| Title | Authors | Details | Keywords |
|---|---|---|---|
| Combined vitamin K2 and D3 therapy improves endoscopic fusion outcomes in osteoporotic lumbar degenerative disease: a prospective study | Yanan Wang, Yidi Wang, Fengming Wang, Zhenyu Wang, Ran Sun, Xiaoling Huang, Song Fu |
Date: May 2025
Category: Clinical Trials
Link: Read
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| Engineering a PhrC-RapC-SinR quorum sensing molecular switch for dynamic fine-tuning of menaquinone-7 synthesis in Bacillus subtilis | Xuli Gao, Yani Luo, Elvis Kwame Adinkra, Yu Chen, Wei Tao, Yongyuan Liu, Mingyu Guo, Jing Wu, Chuanchao Wu, Yan Liu |
Date: Apr 2025
Category: Vitamin K Deficiency
Link: Read
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| MK-4 Ameliorates Diabetic Osteoporosis in Angiogenesis-Dependent Bone Formation by Promoting Mitophagy in Endothelial Cells | Fan Ding, Weidong Zhang, Ting Liu, Xing Rong, Yajun Cui, Lingxiao Meng, Luxu Wang, Bo Liu, Minqi Li |
Date: Mar 2025
Category: Bone Health
Link: Read
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| A High-Throughput Screening Strategy for Bacillus subtilis Producing Menaquinone-7 Based on Fluorescence-Activated Cell Sorting | Lina Yang, Can Tang, Yan Cui, Jianhua Zhang |
Date: Feb 2025
Category: Vitamin K Deficiency
Link: Read
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| Menaquinone-7 and its therapeutic potential in type 2 diabetes mellitus based on a Zucker diabetic fatty rat model | Ingo Mrosewski, Valeriya Mantel, Matthias Urbank, Gundula Schulze-Tanzil, Christian Werner, Clemens Gögele, Maria Kokozidou, Thomas Bertsch |
Date: Dec 2024
Category: Diabetes
Link: Read
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| Nannochloropsis oceanica as a Source of Bioactive Compounds: Mapping the Effects of Cultivation Conditions on Biomass Productivity and Composition Using Response Surface Methodology | Emil Gundersen, Jette Jakobsen, Susan Løvstad Holdt, Charlotte Jacobsen |
Date: Nov 2024
Category: Vitamin K Deficiency
Link: Read
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| Ubiquitous genome streamlined Acidobacteriota in freshwater environments | Hon Lun Wong, Paul-Adrian Bulzu, Rohit Ghai, Maria-Cecilia Chiriac, Michaela M Salcher |
Date: Oct 2024
Category: Vitamin K Deficiency
Link: Read
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| Evaluation of MENAQUINONE-7 and fat-soluble vitamin production by starter cultures during fermentation in dairy products using RPLC method | Vildan Altuncu, Aykut Kaymaz, Bilge Ertekin Filiz, Ebru Çubuk Demiralay, Tuğba Kök Taş |
Date: Oct 2024
Category: Vitamin K Deficiency
Link: Read
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| The Impact of Amine-Functionalised Iron Oxide Nanoparticles on the Menaquinone-7 Isomer Profile and Production of the Bioactive Isomer | Neha Lal, Mostafa Seifan, Alireza Ebrahiminezhad, Aydin Berenjian |
Date: Aug 2024
Category: Vitamin K Deficiency
Link: Read
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| Safety evaluation of vitamin K2 (menaquinone-7) via toxicological tests | Sung-Bong Hwang, Min-Ju Choi, Hyeon-Jeong Lee, Jeong-Jun Han |
Date: Mar 2024
Category: Postmenopausal Women
Link: Read
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| The impact of gut bacteria producing long chain homologs of vitamin K2 on colorectal carcinogenesis | Joanna Smajdor, Katarzyna Jedlińska, Radosław Porada, Anna Górska-Ratusznik, Aleksandra Policht, Małgorzata Śróttek, Grażyna Więcek, Bogusław Baś, Magdalena Strus |
Date: Nov 2023
Category: Vitamin K Deficiency
Link: Read
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| Biomonitoring the skeletal muscle metabolic dysfunction in knee osteoarthritis in older adults: Is Jumpstart Nutrition® Supplementation effective? | Ganguly Apurba, Banerjee Sudip |
Date: Sep 2023
Category: Bone health
Link: Read
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| Vitamin K supplementation and bone mineral density in dialysis: results of the double-blind, randomized, placebo-controlled RenaKvit trial. | Levy-Schousboe K, Marckmann P, Frimodt-Moller M, Peters CD, Kjaergaard KD, Jensen JD, Strandhave C, Sandstrom H, Hitz MF, Langdahl B, Vestergaard P, Brasen CL, Schmedes A, Madsen JS, Jorgensen NR, Frokjaer JB, Frandsen NE, Petersen I, Hansen D |
Date: Sep 2023
Category: Cardiovascular Health
Link: Read
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| Effects of vitamins K2 and D3 supplementation in patients with severe coronary artery calcification: a study protocol for a randomised controlled trial | Selma Hasific, Kristian A Øvrehus, Susanne Hosbond, Jess Lambrechtsen, Preman Kumarathurai, Anna Mejldal, Emil Johannes Ravn, Lars Melholt Rasmussen, Oke Gerke, Hans Mickley, Axel Diederichsen |
Date: Jul 2023
Category: Clinical Trials
Link: Read
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| Does Vitamin K2 Influence the Interplay between Diabetes Mellitus and Intervertebral Disc Degeneration in a Rat Model? | Mohamed Mahmoud, Maria Kokozidou, Clemens Gögele, Christian Werner, Alexander Auffarth, Benjamin Kohl, Ingo Mrosewski, Gundula Gesine Schulze-Tanzil |
Date: Jun 2023
Category: Diabetes
Link: Read
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| Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial. | Naiyarakseree N, Phannajit J, Naiyarakseree W, Mahatanan N, Asavapujanamanee P, Lekhyananda S, Vanichakarn S, Avihingsanon Y, Praditpornsilpa K, Eiam-Ong S, Susantitaphong P |
Date: May 2023
Category: Clinical Trials
Link: Read
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| Effect of vitamin K supplementation on serum calcification propensity and arterial stiffness in vitamin K-deficient kidney transplant recipients: A double-blind, randomized, placebo-controlled clinical trial. | Eelderink C, Kremer D, Riphagen IJ, Knobbe TJ, Schurgers LJ, Pasch A, Mulder DJ, Corpeleijn E, Navis G, Bakker SJL, de Borst MH, Te Velde-Keyzer CA |
Date: Apr 2023
Category: Renal Health
Link: Read
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| Effect of vitamin K2 administration on depression status in patients with polycystic ovary syndrome: a randomized clinical trial. | Tarkesh F, Namavar Jahromi B, Hejazi N, Hoseini G |
Date: Jul 2022
Category: Diabetes
Link: Read
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| Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial. | Diederichsen ACP, Lindholt JS, Moller S, Ovrehus KA, Auscher S, Lambrechtsen J, Hosbond SE, Alan DH, Urbonaviciene G, Becker SW, Fredgart MH, Hasific S, Folkestad L, Gerke O, Rasmussen LM, Moller JE, Mickley H, Dahl JS |
Date: May 2022
Category: Cardiovascular Health
Link: Read
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| The effect of menaquinone-7 supplementation on dp-ucMGP, PIVKAII, inflammatory markers, and body composition in type 2 diabetes patients: a randomized clinical trial. | Karamzad N, Faraji E, Adeli S, Sullman MJM, Pourghassem Gargari B |
Date: Apr 2022
Category: Diabetes
Link: Read
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| Fat-Soluble Vitamin Supplementation Using Liposomes, Cyclodextrins, or Medium-Chain Triglycerides in Cystic Fibrosis: A Randomized Controlled Trial. | Nowak JK, Sobkowiak P, Drzymala-Czyz S, Krzyzanowska-Jankowska P, Sapiejka E, Skorupa W, Pogorzelski A, Nowicka A, Wojsyk-Banaszak I, Kurek S, Zielinska-Psuja B, Lisowska A, Walkowiak J |
Date: Dec 2021
Category: Bone Health
Link: Read
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| Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women: a randomized controlled trial. | Ronn SH, Harslof T, Pedersen SB, Langdahl BL |
Date: Nov 2021
Category: Postmenopausal Women
Link: Read
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| Glycemic control improvement in individuals with type 2 diabetes with vitamin K(2) supplementation: a randomized controlled trial. | Rahimi Sakak F, Moslehi N, Niroomand M, Mirmiran P |
Date: Aug 2021
Category: Diabetes
Link: Read
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| Effects of vitamin K2 supplementation on atherogenic status of individuals with type 2 diabetes: a randomized controlled trial. | Rahimi Sakak F, Moslehi N, Abdi H, Mirmiran P |
Date: May 2021
Category: Diabetes
Link: Read
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| Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective cohort study. | Solmaz I, Ozdemir MA, Unal E, Abdurrezzak U, Muhtaroglu S, Karakukcu M |
Date: Apr 2021
Category: Bone Health
Link: Read
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| Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study. | Zhang Y, Liu Z, Duan L, Ji Y, Yang S, Zhang Y, Li H, Wang Y, Wang P, Chen J, Li Y |
Date: May 2020
Category: Osteoporosis
Link: Read
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| The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial. | Zwakenberg SR, de Jong PA, Bartstra JW, van Asperen R, Westerink J, de Valk H, Slart RHJA, Luurtsema G, Wolterink JM, de Borst GJ, van Herwaarden JA, van de Ree MA, Schurgers LJ, van der Schouw YT, Beulens JWJ |
Date: Oct 2019
Category: Cardiovascular Health
Link: Read
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| Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using (18)F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design. | Peeters FECM, van Mourik MJW, Meex SJR, Bucerius J, Schalla SM, Gerretsen SC, Mihl C, Dweck MR, Schurgers LJ, Wildberger JE, Crijns HJGM, Kietselaer BLJH |
Date: Mar 2018
Category: Clinical Trials
Link: Read
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| Vitamin K-induced effects on body fat and weight: results from a 3-year vitamin K2 intervention study. | Knapen MHJ, Jardon KM, Vermeer C |
Date: Jan 2018
Category: Cardiovascular Health
Link: Read
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| Fecal concentrations of bacterially derived vitamin K forms are associated with gut microbiota composition but not plasma or fecal cytokine concentrations in healthy adults. | Karl JP, Meydani M, Barnett JB, Vanegas SM, Barger K, Fu X, Goldin B, Kane A, Rasmussen H, Vangay P, Knights D, Jonnalagadda SS, Saltzman E, Roberts SB, Meydani SN, Booth SL |
Date: Oct 2017
Category: Nutrition
Link: Read
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| Vitamin K2 supplementation and arterial stiffness among renal transplant recipients-a single-arm, single-center clinical trial. | Mansour AG, Hariri E, Daaboul Y, Korjian S, El Alam A, Protogerou AD, Kilany H, Karam A, Stephan A, Bahous SA |
Date: Sep 2017
Category: Renal Health
Link: Read
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| High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K(2), A pre-post intervention clinical trial. | Aoun M, Makki M, Azar H, Matta H, Chelala DN |
Date: Jun 2017
Category: Renal Health
Link: Read
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| Vitamin K2 (menaquinone-7) prevents age-related deterioration of trabecular bone microarchitecture at the tibia in postmenopausal women. | Ronn SH, Harslof T, Pedersen SB, Langdahl BL |
Date: Dec 2016
Category: Cardiovascular Health
Link: Read
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| Steady-state vitamin K2 (menaquinone-7) plasma concentrations after intake of dairy products and soft gel capsules. | Knapen MH, Braam LA, Teunissen KJ, Van't Hoofd CM, Zwijsen RM, van den Heuvel EG, Vermeer C |
Date: Jul 2016
Category: Clinical Trials
Link: Read
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| Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial). | Vossen LM, Schurgers LJ, van Varik BJ, Kietselaer BL, Vermeer C, Meeder JG, Rahel BM, van Cauteren YJ, Hoffland GA, Rennenberg RJ, Reesink KD, de Leeuw PW, Kroon AA |
Date: Oct 2015
Category: Cardiovascular Health
Link: Read
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| Menaquinone-7 as a novel pharmacological therapy in the treatment of rheumatoid arthritis: A clinical study. | Abdel-Rahman MS, Alkady EA, Ahmed S |
Date: Aug 2015
Category: Clinical Trials
Link: Read
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| Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. | Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C |
Date: May 2015
Category: Cardiovascular Health
Link: Read
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| Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin gamma-Carboxylation: A Double-Blind, Randomized Controlled Trials. | Inaba N, Sato T, Yamashita T |
Date: Jan 2015
Category: Postmenopausal Women
Link: Read
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| Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. | Caluwe R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS |
Date: Jul 2014
Category: Bone Health
Link: Read
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| Dietary intake of vitamin K is inversely associated with mortality risk. | Juanola-Falgarona M, Salas-Salvado J, Martinez-Gonzalez MA, Corella D, Estruch R, Ros E, Fito M, Aros F, Gomez-Gracia E, Fiol M, Lapetra J, Basora J, Lamuela-Raventos RM, Serra-Majem L, Pinto X, Munoz MA, Ruiz-Gutierrez V, Fernandez-Ballart J, Bullo M |
Date: May 2014
Category: Nutrition
Link: Read
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| Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women. | Koitaya N, Sekiguchi M, Tousen Y, Nishide Y, Morita A, Yamauchi J, Gando Y, Miyachi M, Aoki M, Komatsu M, Watanabe F, Morishita K, Ishimi Y |
Date: Mar 2014
Category: Postmenopausal Women
Link: Read
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| Vitamin K status in healthy volunteers | Theuwissen E, Magdeleyns EJ, Braam LA, Teunissen KJ, Knapen MH, Binnekamp IA, van Summeren MJ, Vermeer C |
Date: Feb 2014
Category: Vitamin K Deficiency
Link: Read
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| The efficacy of vitamin K2 and calcitriol combination on thalassemic osteopathy. | Ozdemir MA, Yilmaz K, Abdulrezzak U, Muhtaroglu S, Patiroglu T, Karakukcu M, Unal E |
Date: Nov 2013
Category: Bone Health
Link: Read
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| Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. | Knapen MH, Drummen NE, Smit E, Vermeer C, Theuwissen E |
Date: Sep 2013
Category: Osteoporosis
Link: Read
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| The effect of menaquinone-7 supplementation on circulating species of matrix Gla protein. | Dalmeijer GW, van der Schouw YT, Magdeleyns E, Ahmed N, Vermeer C, Beulens JW |
Date: Dec 2012
Category: Postmenopausal Women
Link: Read
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| Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects. | Theuwissen E, Cranenburg EC, Knapen MH, Magdeleyns EJ, Teunissen KJ, Schurgers LJ, Smit E, Vermeer C |
Date: Nov 2012
Category: Clinical Trials
Link: Read
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| Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. | Sato T, Schurgers LJ, Uenishi K |
Date: Nov 2012
Category: Clinical Trials
Link: Read
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| Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight. | Knapen MH, Schurgers LJ, Shearer MJ, Newman P, Theuwissen E, Vermeer C |
Date: Sep 2012
Category: Clinical Trials
Link: Read
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| Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. | Westenfeld R, Krueger T, Schlieper G, Cranenburg EC, Magdeleyns EJ, Heidenreich S, Holzmann S, Vermeer C, Jahnen-Dechent W, Ketteler M, Floege J, Schurgers LJ |
Date: Feb 2012
Category: Clinical Trials
Link: Read
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| Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylation. | Bruge F, Bacchetti T, Principi F, Littarru GP, Tiano L |
Date: Oct 2011
Category: Postmenopausal Women
Link: Read
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| Possible site-specific effect of an intervention combining nutrition and lifestyle counselling with consumption of fortified dairy products on bone mass: the Postmenopausal Health Study II. | Moschonis G, Kanellakis S, Papaioannou N, Schaafsma A, Manios Y |
Date: Jul 2011
Category: Postmenopausal Women
Link: Read
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| Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial. | Emaus N, Gjesdal CG, Almas B, Christensen M, Grimsgaard AS, Berntsen GK, Salomonsen L, Fonnebo V |
Date: Oct 2010
Category: Osteoporosis
Link: Read
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| The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children. | van Summeren MJ, Braam LA, Lilien MR, Schurgers LJ, Kuis W, Vermeer C |
Date: Oct 2009
Category: Postmenopausal Women
Link: Read
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| Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women. | Binkley N, Harke J, Krueger D, Engelke J, Vallarta-Ast N, Gemar D, Checovich M, Chappell R, Suttie J |
Date: Jun 2009
Category: Bone Health
Link: Read
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| Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women. | Koitaya N, Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, Miyachi M, Sasaki S, Ishimi Y |
Date: Feb 2009
Category: Osteoporosis
Link: Read
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| Excretion of the urinary 5C- and 7C-aglycone metabolites of vitamin K by young adults responds to changes in dietary phylloquinone and dihydrophylloquinone intakes. | Harrington DJ, Booth SL, Card DJ, Shearer MJ |
Date: Jul 2007
Category: Bone Health
Link: Read
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| Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. | Schurgers LJ, Teunissen KJ, Hamulyak K, Knapen MH, Vik H, Vermeer C |
Date: Apr 2007
Category: Nutrition
Link: Read
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| Treatment of natto, a fermented soybean preparation, to prevent excessive plasma vitamin K concentrations in patients taking warfarin. | Homma K, Wakana N, Suzuki Y, Nukui M, Daimatsu T, Tanaka E, Tanaka K, Koga Y, Nakajima Y, Nakazawa H |
Date: Oct 2006
Category: Nutrition
Link: Read
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| Vitamin K(2) (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis. | Miki T, Nakatsuka K, Naka H, Kitatani K, Saito S, Masaki H, Tomiyoshi Y, Morii H, Nishizawa Y |
Date: Jan 2003
Category: Osteoporosis
Link: Read
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| Menaquinone-4 in breast milk is derived from dietary phylloquinone. | Thijssen HH, Drittij MJ, Vermeer C, Schoffelen E |
Date: Mar 2002
Category: Vitamin K Deficiency
Link: Read
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| Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency. | Asakura H, Myou S, Ontachi Y, Mizutani T, Kato M, Saito M, Morishita E, Yamazaki M, Nakao S |
Date: Dec 2001
Category: Osteoporosis
Link: Read
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| Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) treatment in children treated with glucocorticoid and alfacalcidol. | Inoue T, Sugiyama T, Matsubara T, Kawai S, Furukawa S |
Date: Feb 2001
Category: Bone Health
Link: Read
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| Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. | Shiraki M, Shiraki Y, Aoki C, Miura M |
Date: Mar 2000
Category: Osteoporosis
Link: Read
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| Intake of fermented soybean (natto) increases circulating vitamin K2 (menaquinone-7) and gamma-carboxylated osteocalcin concentration in normal individuals. | Tsukamoto Y, Ichise H, Kakuda H, Yamaguchi M |
Date: Jan 2000
Category: Bone Health
Link: Read
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| Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients. | Sato Y, Honda Y, Kuno H, Oizumi K |
Date: Sep 1998
Category: Osteoporosis
Link: Read
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| Anticoagulant effects of warfarin and kinetics of K vitamins in blood and feces. | Nakamura K, Toyohira H, Kariyazono H, Ishibashi M, Saigenji H, Shimokawa S, Taira A |
Date: Jan 1994
Category: Vitamin K Deficiency
Link: Read
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| Vitamin K concentrations in the plasma and liver of surgical patients. | Usui Y, Tanimura H, Nishimura N, Kobayashi N, Okanoue T, Ozawa K |
Date: May 1990
Category: Vitamin K Deficiency
Link: Read
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| Dietary deficiency of phylloquinone and reduced serum levels in febrile neutropenic cancer patients. | Conly J, Suttie J, Reid E, Loftson J, Ramotar K, Louie T |
Date: Jul 1989
Category: Vitamin K Deficiency
Link: Read
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| Menaquinone (vitamin K2) therapy for bronchial asthma. II. Clinical effect of menaquinone on bronchial asthma. | Kimur I, Tanizaki Y, Sato S, Saito K, Takahashi K |
Date: Apr 1975
Category: Bronchial Asthma
Link: Read
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